Cathepsin S Evokes PAR<sub>2</sub>-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models

Cathepsin S Evokes PAR<sub>2</sub>-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models

Oral squamous cell carcinoma (SCC) pain is more prevalent and severe than pain generated by any other form of cancer. We previously showed that protease-activated receptor-2 (PAR<sub>2</sub>) contributes to oral SCC pain. Cathepsin S is a lysosomal cysteine protease released during injur...

Full description

Bibliographic Details
Main Authors: Nguyen Huu Tu, Kenji Inoue, Elyssa Chen, Bethany M. Anderson, Caroline M. Sawicki, Nicole N. Scheff, Hung D. Tran, Dong H. Kim, Robel G. Alemu, Lei Yang, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Rocco Latorre, Dane D. Jensen, Nigel W. Bunnett, Laura E. Edgington-Mitchell, Brian L. Schmidt
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
oral cancer
pain
cathepsin S
protease-activated receptor-2
PAR<sub>2</sub>
cancer pain
Online Access:https://www.mdpi.com/2072-6694/13/18/4697

Internet

https://www.mdpi.com/2072-6694/13/18/4697

Similar Items