Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1
Aggregation-prone proteins in neurodegenerative disease disrupt cellular protein stabilization and degradation pathways. The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is caused by a coding polyglutamine expansion in the Ataxin-1 gene ( ATXN1 ), which gives rise to the aggregatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2015-01-01
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| Series: | Journal of Experimental Neuroscience |
| Online Access: | https://doi.org/10.4137/JEN.S25469 |