Early detection of metastatic uveal melanoma by the analysis of tumor‐specific mutations in cell‐free plasma DNA

Early detection of metastatic uveal melanoma by the analysis of tumor‐specific mutations in cell‐free plasma DNA

Abstract Background Eye salvaging therapy of malignant melanomas of the uvea can preserve the eye in most cases, but still about half of patients die from metastatic disease. Previous analyses of cell‐free DNA from plasma had shown detectable levels of tumor‐specific GNAQ/GNA11 mutations in patients...

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Bibliographic Details
Main Authors: Claudia H. D. Le Guin, Norbert Bornfeld, Nikolaos E. Bechrakis, Leyla Jabbarli, Heike Richly, Dietmar R. Lohmann, Michael Zeschnigk
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Cancer Medicine
Subjects:
cell‐free DNA
cell‐free tumor DNA
deep amplicon sequencing
GNAQ/GNA11
oncogenic mutations
uveal melanoma
Online Access:https://doi.org/10.1002/cam4.4153

Internet

https://doi.org/10.1002/cam4.4153

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