Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome

Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome

<p>Abstract</p> <p>Background</p> <p>X monosomic mice (39,XO) have a remarkably mild phenotype when compared to women with Turner syndrome (45,XO). The generally accepted hypothesis to explain this discrepancy is that the number of genes on the mouse X chromosome which...

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Bibliographic Details
Main Authors: Sargent Carole A, Bauer Julien, Ojarikre Andrew, Burgoyne Paul S, Lopes Alexandra M, Amorim António, Affara Nabeel A
Format: Article
Language:English
Published: BMC 2010-02-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/11/82

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http://www.biomedcentral.com/1471-2164/11/82

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