Molecular Insight Into the IRE1α-Mediated Type I Interferon Response Induced by Proteasome Impairment in Myeloid Cells of the Brain

Molecular Insight Into the IRE1α-Mediated Type I Interferon Response Induced by Proteasome Impairment in Myeloid Cells of the Brain

Proteostasis is critical for cells to maintain the balance between protein synthesis, quality control, and degradation. This is particularly important for myeloid cells of the central nervous system as their immunological function relies on proper intracellular protein turnover by the ubiquitin-prot...

Full description

Bibliographic Details
Main Authors: Maja Studencka-Turski, Gonca Çetin, Heike Junker, Frédéric Ebstein, Elke Krüger
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
UPR
type I IFN response
proteasome
microglia
CANDLE/PRAAS
RIDD
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02900/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02900/full

Similar Items