Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor

Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor

Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer. The induction of hepatic CYP1A, especially CYP1A2, was considered to detoxify AAI so as to reduce its nephrotoxicity. We previously found that baicalin had t...

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Bibliographic Details
Main Authors: Ke Wang, Chenchen Feng, Chenggang Li, Jun Yao, Xiaofeng Xie, Likun Gong, Yang Luan, Guozhen Xing, Xue Zhu, Xinming Qi, Jin Ren
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:International Journal of Molecular Sciences
Subjects:
aristolochic acid
kidney injury
baicalin
aromatic hydrocarbon receptor
CYP1A
Online Access:http://www.mdpi.com/1422-0067/16/7/16454

Internet

http://www.mdpi.com/1422-0067/16/7/16454

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