Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders

Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders

Myeloid cells, including monocytes/macrophages, primarily rely on glucose and lipid metabolism to provide the energy and metabolites needed for their functions and survival. AMP-activated protein kinase (AMPK, its gene is PRKA for human, Prka for rodent) is a key metabolic sensor that regulates many...

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Bibliographic Details
Main Authors: Qiuhua Yang, Qian Ma, Jiean Xu, Zhiping Liu, Jianqiu Zou, Jian Shen, Yaqi Zhou, Qingen Da, Xiaoxiao Mao, Sarah Lu, David J. Fulton, Neal L. Weintraub, Zsolt Bagi, Mei Hong, Yuqing Huo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
AMPKα1/PRKAA1
glycolysis
monocyte recruitment
macrophage viability
metabolic disorders
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.611354/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.611354/full

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