Combined effects of genotype and childhood adversity shape variability of DNA methylation across age

Combined effects of genotype and childhood adversity shape variability of DNA methylation across age

Abstract Lasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk, may be embedded via epigenetic mechanisms but findings from human studies investigating the main effects of such exposure on epigenetic measures, including DNA methylation (DNAm), are inconsistent. S...

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Bibliographic Details
Main Authors: Darina Czamara, Elleke Tissink, Johanna Tuhkanen, Jade Martins, Yvonne Awaloff, Amanda J. Drake, Batbayar Khulan, Aarno Palotie, Sibylle M. Winter, Charles B. Nemeroff, W. Edward Craighead, Boadie W. Dunlop, Helen S. Mayberg, Becky Kinkead, Sanjay J. Mathew, Dan V. Iosifescu, Thomas C. Neylan, Christine M. Heim, Jari Lahti, Johan G. Eriksson, Katri Räikkönen, Kerry J. Ressler, Nadine Provençal, Elisabeth B. Binder
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-020-01147-z

Internet

https://doi.org/10.1038/s41398-020-01147-z

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