Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL

Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL

Abstract Background GATA3 is pivotal for the development of T lymphocytes. While its effects in later stages of T cell differentiation are well recognized, the role of GATA3 in the generation of early T cell precursors (ETP) has only recently been explored. As aberrant GATA3 mRNA expression has been...

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Bibliographic Details
Main Authors: L. Fransecky, M. Neumann, S. Heesch, C. Schlee, J. Ortiz-Tanchez, S. Heller, M. Mossner, S. Schwartz, L. H. Mochmann, K. Isaakidis, L. Bastian, U. R. Kees, T. Herold, K. Spiekermann, N. Gökbuget, C. D. Baldus
Format: Article
Language:English
Published: BMC 2016-09-01
Series:Journal of Hematology & Oncology
Subjects:
GATA3
ETP-ALL
PER-117
Decitabine
Online Access:http://link.springer.com/article/10.1186/s13045-016-0324-8

Internet

http://link.springer.com/article/10.1186/s13045-016-0324-8

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