Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity.

Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity.

While modulation of regulatory T cell (Treg) function and adoptive Treg transfer are being explored as therapeutic modalities in the context of autoimmune diseases, transplantation and cancer, their role in HIV-1 pathogenesis remains less well defined. Controversy persists regarding their beneficial...

Full description

Bibliographic Details
Main Authors: Mathieu Angin, Paul L Klarenbeek, Melanie King, Siddhartha M Sharma, Eshia S Moodley, Ashley Rezai, Alicja Piechocka-Trocha, Ildiko Toth, Andrew T Chan, Philip J Goulder, Thumbi Ndung'u, Douglas S Kwon, Marylyn M Addo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3911933?pdf=render

Internet

http://europepmc.org/articles/PMC3911933?pdf=render

Similar Items