The Effects of PPAR Stimulation on Cardiac Metabolic Pathways in Barth Syndrome Mice

The Effects of PPAR Stimulation on Cardiac Metabolic Pathways in Barth Syndrome Mice

Aim: Tafazzin knockdown (TazKD) in mice is widely used to create an experimental model of Barth syndrome (BTHS) that exhibits dilated cardiomyopathy and impaired exercise capacity. Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that play essential roles...

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Bibliographic Details
Main Authors: Caitlin Schafer, Vicky Moore, Nupur Dasgupta, Sabzali Javadov, Jeanne F. James, Alexander I. Glukhov, Arnold W. Strauss, Zaza Khuchua
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
PPAR agonist
bezafibrate
cardiomyopathy
Ostn
musclin
Barth syndrome
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00318/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00318/full

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