Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank

Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank

Laboratory studies have suggested oncogenic roles of lipids, as well as anticarcinogenic effects of statins. Here we assess the potential effect of statin therapy on cancer risk using evidence from human genetics. We obtained associations of lipid-related genetic variants with the risk of overall an...

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Bibliographic Details
Main Authors: Paul Carter, Mathew Vithayathil, Siddhartha Kar, Rahul Potluri, Amy M Mason, Susanna C Larsson, Stephen Burgess
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
genetic epidemiology
statins
lipids
causal inference
Mendelian randomization
cholesterol
Online Access:https://elifesciences.org/articles/57191

Internet

https://elifesciences.org/articles/57191

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