Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects
Abstract Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopaminergic neurons in vitro and in vivo. For this reason, GDNF is currently in clinical trials for the treatment of Parkinson’s disease (PD). However, how endogenous GDNF influences dopamine system function and an...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-08-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-29988-1 |