Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS

Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS

Pyroptosis is a newly discovered form of cell death. Peroxiredoxin 3 (PRX3) plays a crucial role in scavenging reactive oxygen species (ROS), but its hepatoprotective capacity in acetaminophen (APAP)-induced liver disease remains unclear. The aim of this study was to assess the role of PRX3 in the r...

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Bibliographic Details
Main Authors: Yue Wang, Yan Zhao, Zhecheng Wang, Ruimin Sun, Boyang Zou, Ruixi Li, Deshun Liu, Musen Lin, Junjun Zhou, Shili Ning, Xiaofeng Tian, Jihong Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
PRX3
pyroptosis
mitochondrial ROS (mtROS)
NLRP3 inflammasome
APAP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.652782/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.652782/full

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