High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice

High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice

Background Mycobacterium ulcerans is the causative agent of a debilitating skin and soft tissue infection known as Buruli ulcer (BU). There is no vaccine against BU. The purpose of this study was to investigate the vaccine potential of two previously described immunogenic M. ulcerans proteins, MUL_3...

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Bibliographic Details
Main Authors: Kirstie M. Mangas, Nicholas J. Tobias, Estelle Marion, Jérémie Babonneau, Laurent Marsollier, Jessica L. Porter, Sacha J. Pidot, Chinn Yi Wong, David C. Jackson, Brendon Y. Chua, Timothy P. Stinear
Format: Article
Language:English
Published: PeerJ Inc. 2020-08-01
Series:PeerJ
Subjects:
Mycobacterium ulcerans
Buruli ulcer
Vaccination
Mycobacterium
Subunit vaccine
ELISA
Online Access:https://peerj.com/articles/9659.pdf

Internet

https://peerj.com/articles/9659.pdf

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