Expanding the genome-targeting scope and the site selectivity of high-precision base editors

Base editors can be limited by precision and the size of the target window. Here the authors test Cas9s that recognise alternative PAMs to obtain a series of high-precision editors.

Bibliographic Details
Main Authors: Junjie Tan, Fei Zhang, Daniel Karcher, Ralph Bock
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14465-z