Dietary administration of β-ionone epoxide to Sprague-Dawley rats for 90 days

Dietary administration of β-ionone epoxide to Sprague-Dawley rats for 90 days

In a 90-day GLP-compliant study groups of Sprague-Dawley rats (10/sex/group) were fed diets containing β-ionone epoxide, a fragrance material and a flavoring substance, at dietary concentrations providing target intakes of 0, 20, 40 and 80 mg/kg bw/day. There were no deaths and no adverse changes in...

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Bibliographic Details
Main Authors: Vivian Lu, Maria Bastaki, Anne Marie Api, Michel Aubanel, Mark Bauter, Thierry Cachet, Jan Demyttenaere, Maodo Malick Diop, Christie L. Harman, Shim-mo Hayashi, Gerhard Krammer, Odete Mendes, Kevin J. Renskers, Jürgen Schnabel, Sean V. Taylor
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Current Research in Toxicology
Subjects:
beta-Ionone epoxide
FEMA GRAS
flavoring ingredient
fragrance material
Rat
Toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X21000189

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http://www.sciencedirect.com/science/article/pii/S2666027X21000189

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