A modified RP-HPLC method for the determination of the pKa values of synthesized β-hydroxy-β-arylalkanoic acids

A modified RP-HPLC method for the determination of the pKa values of synthesized β-hydroxy-β-arylalkanoic acids

The pKa values of twelve β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using a modified RP-HPLC method. The stationary phase was octadecyl modified (C-18) silica gel, and the mobile phases were mixtures of methanol and one of ten different buffers (60:40 volume ratio). The mean retent...

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Bibliographic Details
Main Authors: Savić Jelena S., Dilber Sanda P., Vujić Zorica B., Vladimirov Sote M., Brborić Jasmina S.
Format: Article
Language:English
Published: Serbian Chemical Society 2018-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
dissociation constant
anti-inflammatory compounds
ibuprofen
liquid chromatography
carboxylic acids
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2018/0352-51391800045S.pdf

Internet

http://www.doiserbia.nb.rs/img/doi/0352-5139/2018/0352-51391800045S.pdf

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