Development of Human Monoclonal Antibody for Claudin-3 Overexpressing Carcinoma Targeting

Development of Human Monoclonal Antibody for Claudin-3 Overexpressing Carcinoma Targeting

Most malignant tumors originate from epithelial tissues in which tight junctions mediate cell−cell interactions. Tight junction proteins, especially claudin-3 (CLDN3), are overexpressed in various cancers. Claudin-3 is exposed externally during tumorigenesis making it a potential biomarker...

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Bibliographic Details
Main Authors: Hobin Yang, Hayeon Park, Yong Jin Lee, Jun Young Choi, TaeEun Kim, Nirmal Rajasekaran, Saehyung Lee, Kyoung Song, Sungyoul Hong, Joon-Seok Choi, Hyunbo Shim, Young-Deug Kim, Soohyun Hwang, Yoon-La Choi, Young Kee Shin
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Biomolecules
Subjects:
claudin
tight junction
epithelial tumor
human monoclonal antibody
Online Access:https://www.mdpi.com/2218-273X/10/1/51

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https://www.mdpi.com/2218-273X/10/1/51

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