Mutations in the C-terminus of HBoV NS1 affect the function of NP1

Abstract Human bocavirus 1 (HBoV1) is an autonomous parvovirus in the Bocaparvovirus genus. The multifunctional nuclear protein NP1 is involved in viral replication. In the present study, we found that the mutations in the C-terminus of NS1 affected NP1 function in viral replication. Knocking out NP...

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Bibliographic Details
Main Authors: Junmei Zhang, Yan Bai, Bing Zhu, Sujuan Hao, Zhen Chen, Hanzhong Wang, Wuxiang Guan
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06513-4