VEGF-C promotes the development of lymphatics in bone and bone loss

VEGF-C promotes the development of lymphatics in bone and bone loss

Patients with Gorham-Stout disease (GSD) have lymphatic vessels in their bones and their bones gradually disappear. Here, we report that mice that overexpress VEGF-C in bone exhibit a phenotype that resembles GSD. To drive VEGF-C expression in bone, we generated Osx-tTA;TetO-Vegfc double-transgenic...

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Bibliographic Details
Main Authors: Devon Hominick, Asitha Silva, Noor Khurana, Ying Liu, Paul C Dechow, Jian Q Feng, Bronislaw Pytowski, Joseph M Rutkowski, Kari Alitalo, Michael T Dellinger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
lymphangiogenesis
lymphatic diseases
lymphatic anomalies
Online Access:https://elifesciences.org/articles/34323

Internet

https://elifesciences.org/articles/34323

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