Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes

The origin of ‘orphan’ genes, species-specific sequences that lack detectable homologues, has remained mysterious since the dawn of the genomic era. There are two dominant explanations for orphan genes: complete sequence divergence from ancestral genes, such that homologues are not readily detectabl...

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Bibliographic Details
Main Authors: Nikolaos Vakirlis, Anne-Ruxandra Carvunis, Aoife McLysaght
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/53500