Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis.

Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis.

Anterior cruciate ligament (ACL) transection surgery in the minipig induces post-traumatic osteoarthritis (PTOA) in a pattern similar to that seen in human patients after ACL injury. Prior studies have reported the presence of cartilage matrix-degrading proteases, such as Matrix metalloproteinase-1...

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Bibliographic Details
Main Authors: Ugur M Ayturk, Jakob T Sieker, Carla M Haslauer, Benedikt L Proffen, Manuela H Weissenberger, Matthew L Warman, Braden C Fleming, Martha M Murray
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229449

Internet

https://doi.org/10.1371/journal.pone.0229449

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