MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer

MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer

Head and Neck Squamous Cell Cancer (HNSCC) presents with multiple treatment challenges limiting overall survival rates and affecting patients' quality of life. Amongst these, resistance to radiation therapy constitutes a major clinical problem in HNSCC patients compounded by origin, location, a...

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Bibliographic Details
Main Authors: Kirtikar Shukla, Naveen Singh, Joshua E. Lewis, Allen W. Tsang, David A. Boothman, Melissa L. Kemp, Cristina M. Furdui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Oncology
Subjects:
head and neck cancer
radiation resistance
NQO1
β-lapachone
MTHFD2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.536377/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.536377/full

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