A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function

A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function

Intracisternal A-particles (IAPs) are endogenous retroviruses (ERVs) responsible for most insertional mutations in the mouse. Full-length IAPs harbour genes flanked by long terminal repeats (LTRs). Here, we identify a solo LTR IAP variant (Iap5-1solo) recently formed in the inbred C57BL/6J mouse str...

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Bibliographic Details
Main Authors: Tessa M Bertozzi, Nozomi Takahashi, Geula Hanin, Anastasiya Kazachenka, Anne C Ferguson-Smith
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
endogenous retrovirus
transposable element
IAP
DNA methylation
epiallele
Online Access:https://elifesciences.org/articles/65233

Internet

https://elifesciences.org/articles/65233

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