Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

Pregnancy-related hormones (PRH) are recognized as important regulators of hepatic cytochrome P450 enzyme expression and function. However, the impact of PRH on the hepatic expression and function of uridine diphosphate glucuronosyltransferases (UGTs) remains unclear. Using primary human hepatocytes...

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Bibliographic Details
Main Authors: Raju Khatri, John K. Fallon, Craig Sykes, Natasha Kulick, Rebecca J. B. Rementer, Taryn A. Miner, Amanda P. Schauer, Angela D. M. Kashuba, Kim A. Boggess, Kim L. R. Brouwer, Philip C. Smith, Craig R. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
pregnancy
uridine diphosphate glucuronosyltransferases
hepatic metabolism
estradiol
progesterone
labetalol
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.655320/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.655320/full

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