Immunization with Human Cytomegalovirus Core Fusion Machinery and Accessory Envelope Proteins Elicit Strong Synergistic Neutralizing Activities

Immunization with Human Cytomegalovirus Core Fusion Machinery and Accessory Envelope Proteins Elicit Strong Synergistic Neutralizing Activities

Human cytomegalovirus (HCMV) core fusion machinery proteins gB and gH/gL, and accessory proteins UL128/UL130/UL131A, are the key envelope proteins that mediate HCMV entry into and infection of host cells. To determine whether these HCMV envelope proteins could elicit neutralizing activities synergis...

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Bibliographic Details
Main Authors: Xinle Cui, Zhouhong Cao, Shuishu Wang, Stuart P. Adler, Michael A. McVoy, Clifford M. Snapper
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Vaccines
Subjects:
human cytomegalovirus
solid organ and hematopoietic stem cell transplantation
congenital infection
HCMV vaccine development
core fusion machinery
envelope glycoprotein
Online Access:https://www.mdpi.com/2076-393X/8/2/179

Internet

https://www.mdpi.com/2076-393X/8/2/179

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