Protective CD8+ T-cell response against Hantaan virus infection induced by immunization with designed linear multi-epitope peptides in HLA-A2.1/Kb transgenic mice

Abstract Background An effective vaccine that prevents disease caused by hantaviruses is a global public health priority, but up to now, no vaccine has been approved for worldwide use. Therefore, novel vaccines with high prophylaxis efficacy are urgently needed. Methods Herein, we designed and synth...

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Bibliographic Details
Main Authors: Ying Ma, Kang Tang, Yusi Zhang, Chunmei Zhang, Linfeng Cheng, Fanglin Zhang, Ran Zhuang, Boquan Jin, Yun Zhang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Virology Journal
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12985-020-01421-y