Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.

Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.

<h4>Background</h4>Albeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the production of MHC class I-restric...

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Bibliographic Details
Main Authors: Michele Mishto, Elena Bellavista, Claudia Ligorio, Kathrin Textoris-Taube, Aurelia Santoro, Mara Giordano, Sandra D'Alfonso, Florinda Listì, Benedetta Nacmias, Elena Cellini, Maurizio Leone, Luigi M E Grimaldi, Chiara Fenoglio, Federica Esposito, Filippo Martinelli-Boneschi, Daniela Galimberti, Elio Scarpini, Ulrike Seifert, Maria Pia Amato, Calogero Caruso, Maria P Foschini, Peter M Kloetzel, Claudio Franceschi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20174631/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20174631/?tool=EBI

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