Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells

Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells

Abstract Background Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon. While APOBEC3A edits many mRNAs in monocytes and macrophages in response to hypoxia...

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Bibliographic Details
Main Authors: Shraddha Sharma, Jianmin Wang, Emad Alqassim, Scott Portwood, Eduardo Cortes Gomez, Orla Maguire, Per H. Basse, Eunice S. Wang, Brahm H. Segal, Bora E. Baysal
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Genome Biology
Subjects:
RNA editing
APOBEC3
NK cells
Hypoxia
Cell stress
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s13059-019-1651-1

Internet

http://link.springer.com/article/10.1186/s13059-019-1651-1

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