K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder

SUMMARY The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of mutated Fgfr3 to the murine urothelium using...

Full description

Bibliographic Details
Main Authors: Imran Ahmad, Lukram Babloo Singh, Mona Foth, Carol-Ann Morris, Makoto Mark Taketo, Xue-Ru Wu, Hing Y. Leung, Owen J. Sansom, Tomoko Iwata
Format: Article
Language:English
Published: The Company of Biologists 2011-07-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/4/4/548

Internet

http://dmm.biologists.org/content/4/4/548

Similar Items