CART<i>math</i>—A Mathematical Model of CAR-T Immunotherapy in Preclinical Studies of Hematological Cancers

CART<i>math</i>—A Mathematical Model of CAR-T Immunotherapy in Preclinical Studies of Hematological Cancers

Immunotherapy has gained great momentum with chimeric antigen receptor T cell (CAR-T) therapy, in which patient’s T lymphocytes are genetically manipulated to recognize tumor-specific antigens, increasing tumor elimination efficiency. In recent years, CAR-T cell immunotherapy for hematological malig...

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Bibliographic Details
Main Authors: Luciana R. C. Barros, Emanuelle A. Paixão, Andrea M. P. Valli, Gustavo T. Naozuka, Artur C. Fassoni, Regina C. Almeida
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
three-population mathematical model
CAR-T lymphocytes
memory CAR-T cells
long-term immunity
tumor-induced immunosuppression
Online Access:https://www.mdpi.com/2072-6694/13/12/2941

Internet

https://www.mdpi.com/2072-6694/13/12/2941

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