A Novel Small Peptide Inhibitor of NFκB, RH10, Blocks Oxidative Stress-Dependent Phenotypes in Cancer

Background. The RH domain of GRK5 is an effective modulator of cancer growth through the inhibition of NFκB activity. The aim of this study was to identify the minimum effective sequence of RH that is still able to inhibit tumor growth and could be used as a peptide-based drug for therapy. Methods....

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Bibliographic Details
Main Authors: Jessica Gambardella, Michele Ciccarelli, Carmine Del Giudice, Antonella Fiordelisi, Matteo De Rosa, Marina Sala, Roberto Pacelli, Pietro Campiglia, Bruno Trimarco, Guido Iaccarino, Daniela Sorriento
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2018/5801807