Determining 8-oxo-2’-deoxyguanosine/2’-deoxyguanosine ratio in DNA by reverse phase HPLC combined with amperometric detection

Determining 8-oxo-2’-deoxyguanosine/2’-deoxyguanosine ratio in DNA by reverse phase HPLC combined with amperometric detection

The article presents an optimized method for the determination of the ratio of 8-oxo-2'-deoxyguanosine (formed in DNA due to the action of active forms of oxygen) to 2'-deoxyguanosine. The ratio was determined by reverse phase HPLC combined with amperometric detection. It was shown that th...

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Bibliographic Details
Main Authors: D. S. Esipov, E. V. Sidorenko, O. V. Esipova, T. A. Gorbacheva, T. S. Nevredimova, A. L. Krushinskiy, V. S. Kuzenkov, V. P. Reutov
Format: Article
Language:Russian
Published: MIREA - Russian Technological University 2010-06-01
Series:Тонкие химические технологии
Subjects:
8-oxo-2'-deoxyguanosine
oxidative stress
ascorbic acid
reverse phase hplc
amperometric detection
Online Access:https://www.finechem-mirea.ru/jour/article/view/976

Internet

https://www.finechem-mirea.ru/jour/article/view/976

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