Leishmania amazonensis-Induced cAMP Triggered by Adenosine A2B Receptor Is Important to Inhibit Dendritic Cell Activation and Evade Immune Response in Infected Mice

Leishmania amazonensis-Induced cAMP Triggered by Adenosine A2B Receptor Is Important to Inhibit Dendritic Cell Activation and Evade Immune Response in Infected Mice

Differently from others Leishmania species, infection by the protozoan parasite L. amazonensis is associated with a lack of antigen-specific T-cell responses. Dendritic cells (DC) are essential for the innate immune response and for directing the differentiation of T-helper lymphocytes. Previously,...

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Bibliographic Details
Main Authors: Amanda Braga Figueiredo, Míriam Conceição Souza-Testasicca, Tiago Wilson Patriarca Mineo, Luís Carlos Crocco Afonso
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
A2B adenosine receptor
cAMP
extracellular signal-regulated protein kinases
CD40
IL-12p70
dendritic cell
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00849/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00849/full

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