Perampanel Affects Up-Stream Regulatory Signaling Pathways of GluA1 Phosphorylation in Normal and Epileptic Rats

Perampanel Affects Up-Stream Regulatory Signaling Pathways of GluA1 Phosphorylation in Normal and Epileptic Rats

To elucidate the pharmacological properties of perampanel [2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile, a novel non-competitive antagonist of AMPA receptor], we investigated its effects on the up-stream regulatory pathways of GluA1 phosphorylation including protein kinase C...

Full description

Bibliographic Details
Main Authors: Ji-Eun Kim, Hui-Chul Choi, Hong-Ki Song, Tae-Cheon Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
BIM
CAMKII
cyclosporin A
ERK1/2
H-89
JNK
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00080/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00080/full

Similar Items