MCP-1 Stimulates MMP-9 Expression via ERK 1/2 and p38 MAPK Signaling Pathways in Human Aortic Smooth Muscle Cells

MCP-1 Stimulates MMP-9 Expression via ERK 1/2 and p38 MAPK Signaling Pathways in Human Aortic Smooth Muscle Cells

Objective: We investigated the molecular mechanism underlying the role of monocyte chemoattractant protein-1 (MCP-1) in the formation and development of human abdominal aortic aneurysm (AAA). Methods: We examined protein expression profiles using a protein array and found that MCP-1 was the most hig...

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Bibliographic Details
Main Authors: Ci-Qiu Yang, Wen Li, Song-Qi Li, Jie Li, Yu-Wen Li, Shu-Xin Kong, Rui-Ming Liu, Shen-Ming Wang, Wei-Ming Lv
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
p38 mitogen activated protein kinases
Matrix metalloproteinase-9
Abdominal aortic aneurysm
Monocyte chemoattractant protein-1
Human aortic vascular smooth cells
Extracellular signal regulated kinase
c-Jun amino terminal kinase
Online Access:http://www.karger.com/Article/FullText/362997

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http://www.karger.com/Article/FullText/362997

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