Characterization of Phase I Hepatic Metabolites of Anti-Premature Ejaculation Drug Dapoxetine by UHPLC-ESI-Q-TOF

Characterization of Phase I Hepatic Metabolites of Anti-Premature Ejaculation Drug Dapoxetine by UHPLC-ESI-Q-TOF

Determination of the metabolism pathway of xenobiotics undergoing the hepatic pass is a crucial aspect in drug development since the presence of toxic biotransformation products may result in significant side effects during the therapy. In this study, the complete hepatic metabolism pathway of dapox...

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Bibliographic Details
Main Authors: Robert Skibiński, Jakub Trawiński, Maciej Gawlik
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
mass spectrometry
chromatography
metabolites
biotransformation
HLM
in silico toxicity
Online Access:https://www.mdpi.com/1420-3049/26/13/3794

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https://www.mdpi.com/1420-3049/26/13/3794

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