Suppressive effects of the neutrophil elastase inhibitor sivelestat sodium hydrate on interleukin-1β production in lipopolysaccharide-stimulated porcine whole blood

Suppressive effects of the neutrophil elastase inhibitor sivelestat sodium hydrate on interleukin-1β production in lipopolysaccharide-stimulated porcine whole blood

Objective: Sivelestat sodium hydrate (Siv) is expected to be an effective therapy for acute respiratory distress syndrome, although its mechanism of action is not understood. In this study, we investigated which myeloid cells-derived cytokines were suppressed by Siv. Methods: Continuous hemofiltrati...

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Bibliographic Details
Main Authors: Yasuyoshi Kurimoto, Yasuyo Shimomura, Kazuhiro Moriyama, Tomoyuki Nakamura, Naohide Kuriyama, Yoshitaka Hara, Hidefumi Komura, Daisuke Hasegawa, Takahiro Kawaji, Osamu Nishida
Format: Article
Language:English
Published: Fujita Medical Society 2020-02-01
Series:Fujita Medical Journal
Subjects:
sivelestat sodium hydrate
acute respiratory distress syndrome
myeloid cell
cytokine
Online Access:https://www.jstage.jst.go.jp/article/fmj/6/1/6_2019-002/_pdf/-char/en

Internet

https://www.jstage.jst.go.jp/article/fmj/6/1/6_2019-002/_pdf/-char/en

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