Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress res...

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Bibliographic Details
Main Authors: Liou Y Sun, Adam Spong, William R Swindell, Yimin Fang, Cristal Hill, Joshua A Huber, Jacob D Boehm, Reyhan Westbrook, Roberto Salvatori, Andrzej Bartke
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-10-01
Series:eLife
Subjects:
mice
aging
caloric restriction
growth hormone
Online Access:https://elifesciences.org/articles/01098

Internet

https://elifesciences.org/articles/01098

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