Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice
We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress res...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2013-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/01098 |