Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension

Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension

Losartan, an AT1 angiotensin II (ANG II) receptor non-peptide antagonist, induces an increase in mean arterial pressure (MAP) when injected intracerebroventricularly (icv) into rats. The present study investigated possible effector mechanisms of the increase in MAP induced by icv losartan in unanest...

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Bibliographic Details
Main Authors: A.M. Sugawara, R.C. Vendramini, S.P. Barbosa, I.L. Brunetti, J.V. Menani, L.A. De Luca Jr.
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2002-09-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Angiotensin II
alpha1-Adrenoceptors
Arterial pressure
AT1 receptors
Angiotensin-converting enzyme
Renin
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900007

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900007

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