Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice

Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice

Abstract Background DNA-dependent protein kinase (DNA-PK), consisting of a Ku heterodimer (Ku70/80) and a large catalytic subunit (DNA-PKcs), plays an important role in the repair of DNA double-strand breaks via non-homologous end-joining (NHEJ) in mammalian cells. Severe combined immunodeficient (s...

Full description

Bibliographic Details
Main Authors: Kenichi Masumura, Fumio Yatagai, Masako Ochiai, Hitoshi Nakagama, Takehiko Nohmi
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Genes and Environment
Subjects:
DNA-PKcs
scid mice
Non-homologous end-joining
Spi− assay
Deletion
X-irradiation
Online Access:http://link.springer.com/article/10.1186/s41021-020-00158-y

Internet

http://link.springer.com/article/10.1186/s41021-020-00158-y

Similar Items