Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion.

Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion.

Both constitutive secretion and Ca(2+)-regulated exocytosis require the assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes. At present, little is known about how the SNARE complexes mediating these two distinct pathways differ in structure. Using...

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Bibliographic Details
Main Authors: Robert D Lagow, Hong Bao, Evan N Cohen, Richard W Daniels, Aleksej Zuzek, Wade H Williams, Gregory T Macleod, R Bryan Sutton, Bing Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.0050072

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https://doi.org/10.1371/journal.pbio.0050072

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