FoxM1-dependent and fatty acid oxidation-mediated ROS modulation is a cell-intrinsic drug resistance mechanism in cancer stem-like cells

FoxM1-dependent and fatty acid oxidation-mediated ROS modulation is a cell-intrinsic drug resistance mechanism in cancer stem-like cells

Increased oxidative phosphorylation (OXPHOS) and reactive oxygen species (ROS) levels are inherently linked. ROS are essential signaling molecules, with detrimental effects when produced in excess during chemotherapy, leading to cell death. Cancer stem-like cells (CSCs) are a subpopulation of tumor...

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Bibliographic Details
Main Authors: Hae-Ji Choi, Yoo-Lim Jhe, Jungmin Kim, Ju Yeon Lim, Jae Eun Lee, Min-Kyue Shin, Jae-Ho Cheong
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Oxidative phosphorylation
Reactive oxygen species
Cancer stem-like cell
FoxM1
Fatty acid oxidation
Prx3
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720302597

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http://www.sciencedirect.com/science/article/pii/S2213231720302597

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