Modeling drug mechanism of action with large scale gene-expression profiles using GPAR, an artificial intelligence platform

Modeling drug mechanism of action with large scale gene-expression profiles using GPAR, an artificial intelligence platform

Abstract Background Querying drug-induced gene expression profiles with machine learning method is an effective way for revealing drug mechanism of actions (MOAs), which is strongly supported by the growth of large scale and high-throughput gene expression databases. However, due to the lack of code...

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Bibliographic Details
Main Authors: Shengqiao Gao, Lu Han, Dan Luo, Gang Liu, Zhiyong Xiao, Guangcun Shan, Yongxiang Zhang, Wenxia Zhou
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Bioinformatics
Subjects:
MOA
Deep learning
Gene expression profiles
L1000
Online Access:https://doi.org/10.1186/s12859-020-03915-6

Internet

https://doi.org/10.1186/s12859-020-03915-6

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