A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation

A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation

Adaptation of glioblastoma to caloric restriction induces compensatory changes in tumor metabolism that are incompletely known. Here we show that in human glioblastoma cells maintained in exhausted medium, SHC adaptor protein 3 (SHC3) increases due to down-regulation of SHC3 protein degradation. Thi...

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Bibliographic Details
Main Authors: Alberto Azzalin, Francesca Brambilla, Eloisa Arbustini, Katia Basello, Attilio Speciani, Pierluigi Mauri, Paola Bezzi, Lorenzo Magrassi
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
glioblastoma cells
aerobic glycolysis
GLUT/SLC2A
SHC3
PARP1
Online Access:https://www.mdpi.com/2073-4409/9/5/1249

Internet

https://www.mdpi.com/2073-4409/9/5/1249

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