A linear relationship between crystal size and fragment binding time observed crystallographically: implications for fragment library screening using acoustic droplet ejection.

A linear relationship between crystal size and fragment binding time observed crystallographically: implications for fragment library screening using acoustic droplet ejection.

High throughput screening technologies such as acoustic droplet ejection (ADE) greatly increase the rate at which X-ray diffraction data can be acquired from crystals. One promising high throughput screening application of ADE is to rapidly combine protein crystals with fragment libraries. In this a...

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Bibliographic Details
Main Authors: Krystal Cole, Christian G Roessler, Elizabeth A Mulé, Emma J Benson-Xu, Jeffrey D Mullen, Benjamin A Le, Alanna M Tieman, Claire Birone, Maria Brown, Jesus Hernandez, Sherry Neff, Daniel Williams, Marc Allaire, Allen M Orville, Robert M Sweet, Alexei S Soares
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4079544?pdf=render

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http://europepmc.org/articles/PMC4079544?pdf=render

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