Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice

Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice

miR-29 is expressed strongly in the brain and alterations in expression have been linked to several neurological disorders. To further explore the function of this miRNA in the brain, we generated miR-29a/b-1 knockout animals. Knockout mice develop a progressive disorder characterized by locomotor i...

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Bibliographic Details
Main Authors: Aikaterini S. Papadopoulou, Lutgarde Serneels, Tilmann Achsel, Wim Mandemakers, Zsuzsanna Callaerts-Vegh, James Dooley, Pierre Lau, Torik Ayoubi, Enrico Radaelli, Marco Spinazzi, Melanie Neumann, Sébastien S. Hébert, Asli Silahtaroglu, Adrian Liston, Rudi D'Hooge, Markus Glatzel, Bart De Strooper
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
miR-29a/b-1 cluster knockout
Ataxia
Locomotor behavior
Cerebellum
Purkinje cells
Dendrites
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611400299X

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http://www.sciencedirect.com/science/article/pii/S096999611400299X

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