The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles.

The dense-core vesicle is a secretory organelle that mediates the regulated release of peptide hormones, growth factors, and biogenic amines. Dense-core vesicles originate from the trans-Golgi of neurons and neuroendocrine cells, but it is unclear how this specialized organelle is formed and acquire...

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Bibliographic Details
Main Authors: Irini Topalidou, Jérôme Cattin-Ortolá, Andrea L Pappas, Kirsten Cooper, Gennifer E Merrihew, Michael J MacCoss, Michael Ailion
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4871572?pdf=render