Quantitation of the latent HIV-1 reservoir from the sequence diversity in viral outgrowth assays

Quantitation of the latent HIV-1 reservoir from the sequence diversity in viral outgrowth assays

Abstract Background The ability of HIV-1 to integrate into the genomes of quiescent host immune cells, establishing a long-lived latent viral reservoir (LVR), is the primary obstacle to curing these infections. Quantitative viral outgrowth assays (QVOAs) are the gold standard for estimating the size...

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Bibliographic Details
Main Authors: Art F. Y. Poon, Jessica L. Prodger, Briana A. Lynch, Jun Lai, Steven J. Reynolds, Jingo Kasule, Adam A. Capoferri, Susanna L. Lamers, Christopher W. Rodriguez, Daniel Bruno, Stephen F. Porcella, Craig Martens, Thomas C. Quinn, Andrew D. Redd
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Retrovirology
Subjects:
Latent viral reservoir
HIV-1
Viral outgrowth assay
Limiting dilution assay
Next-generation sequencing
Bayesian inference
Online Access:http://link.springer.com/article/10.1186/s12977-018-0426-1

Internet

http://link.springer.com/article/10.1186/s12977-018-0426-1

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